Why do we prefer TOFs over Orbitraps for flow injection analysis?
Background For >10 years, we analysed all kinds of samples by flow injection analysis - HRMS. I will not discuss the pros and cons of including a column (LC-MS) or omitting it (FIA-MS). In brief, FIA-MS is great to profile endogenous metabolites from cellular systems, less for the more exotic samples that require in-depth MS2. Believe it or not, we used FIA to profile>1.4…