On the benefits and role of electron-induced dissociation in lipidomics
One of the grand challenges in metabolomics using mass spectrometry (MS) is the limited and somewhat redundant information provided by collision-induced dissociation (CID). CID is incredibly versatile and quick but tends to fragment weaker bonds, such as C-O bonds. This bias allows us to easily observe fragments indicative of specific functional groups—such as ethanolamine, phosphatidic groups, and glucuronic conjugates—that are diagnostic for certain compound…